ABSTRACT
Background: The use of complementary and alternative medicine [CAM] is becoming increasingly popular in Middle Eastern countries; it is often used for paediatric medical conditions such as chronic gastrointestinal complaints and failure to thrive. It is also commonly used in patients with chronic hepatic conditions such as cirrhosis and in hepatic transplant patients.
Aims: This study aimed to evaluate the prevalence, types and associated factors of CAM use in children with hepatogastrointestinal disease in Shiraz, Islamic Republic of Iran.
Methods: In a cross-sectional study carried out during September 2013January 2014, 238 parents of children attending a paediatric gastroenterology and hepatology clinic at Shiraz University of Medical Sciences received a self-administered questionnaire covering associated factors of complementary and alternative medicine use; 210 questionnaires were completed and returned.
Results: Complementary and alternative medicine was used by 103 patients [49%]; 74 [71.8%] of these used herbal remedies. Older age of the child significantly increased CAM use. Those with previous positive experience of CAM [62.1% of users, 40.2% of non-users] and those who had received recommendation for CAM by health care providers [24.3% of users, 6.6% of non-users] were significantly more likely to use CAM.
Conclusions: This survey demonstrated the high prevalence of CAM use [especially herbal remedies] in paediatric patients with hepatogastrointestinal diseases.
Subject(s)
Humans , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Pediatrics , Gastrointestinal Diseases , Liver Diseases , Cross-Sectional Studies , Surveys and Questionnaires , Child , PrevalenceABSTRACT
Background: Caustic ingestion is one of the most important injuries during childhood, which leads to serious sequel. In this study, we evaluated the clinical manifestations, endoscopic appearance, complications, and treatment results in patients with caustic ingestion in our hospital
Methods: Hospital chart of patients with caustic ingestion who admitted to Nemazee Teaching Hospital affiliated to Shiraz University of Medical Sciences during a 2-year period [2015-2016] were reviewed retrospectively. The age, sex, nature of the caustic agent, clinical presentations, grade of injury in endoscopy, degree of parents' education, site of ingestion, accidental or intentional attempts, complications, and outcomes were reviewed
Results: In this study the charts of 41 patients [26 boys and 15 girls] with caustic ingestion over the 2-year period were reviewed. The mean age of the patients was 4.4 year. Of them, 95.1% had ingested the materials accidentally, and 2 [4.9%] patients had ingested unknown substances for suicidal attempt. Of all cases, 68.3% of caustic ingestion occurred in the kitchen. 19 [46.3%] agents were acidic substances and 17 [41.5%] were alkali agents. 5 [12.1%] patients ingested unknown substances. 24.3% of the patients were asymptomatic and the most common presentation was drooling [34.14%]. 26.8% of the patients had dysphagia, and 24.3% presented with oral ulcer. 7.3% had abdominal pain, 4.8% had fever, and 2.4% had hematemesis. 14 [34.1%] patients had normal feature, 6 [14.6%] had grade I injury, 12 [29.3%] had grade II injury, and 8 [19.5%] had grade III injury in endoscopic evaluation
Conclusion: Most of the caustic ingestion occurred in kitchen. Male was the dominant sex in the caustic injury
Subject(s)
Humans , Male , Female , Child, Preschool , Child , Esophagus/injuries , Endoscopy, Digestive System , Child , Retrospective StudiesABSTRACT
Background: Wilson disease [WD] is caused by numerous pathogenic mutations of the ATP7B gene. There are several mutation screening methods that can be used for the diagnosis and carrier detection of WD, however such methods are costly and time-consuming. Therefore, other diagnostic methods should be used for urgent situations such as prenatal diagnosis
Objective: To report common polymorphisms of ATP7B gene in WD patients from southern Iran to be use in linkage analysis in the WD affected families
Material and methods: Genomic DNA was extracted from 30 patients and PCR was carried out for ATP7B gene. DHPLC was then performed and PCR products with abnormal peak profiles were subjected to direct DNA sequencing
Result: Several patients showed abnormal peak profiles in DHPLC analysis and subsequent sequencing results demonstrated that some polymorphisms were more common in southern Iran. Those were c.1216T>G [exon 2], c.1366C>G [exon 3], c.3419 T>C [exon 16], c.3903 + 6C>T [intron 18] and c.4021+50G>C [intron 19]
Conclusion: These common polymorphisms can be used by linkage analysis for the prenatal diagnosis and carrier detection in affected families with Wilson disease